A giant alien spider escapes from a military lab and rampages the city of Los Angeles. When a massive military strike fails, it is up to a team of scientists and one clever exterminator to kill the creature before the city is destroyed.

After a convoy of American soldiers disappears, a special ops team is deployed to rescue them. They soon encounter an army of gigantic scorpions, spiders and snakes that have come to Earth from another dimension.

After Peter Parker is bitten by a genetically altered spider, he gains newfound, spider-like powers and ventures out to save the city from the machinations of a mysterious reptilian foe.