Miles Morales catapults across the Multiverse, where he encounters a team of Spider-People charged with protecting its very existence. When the heroes clash on how to handle a new threat, Miles must redefine what it means to be a hero.

On the run in the year 1987, Bumblebee finds refuge in a junkyard in a small California beach town. On the cusp of turning 18 and trying to find her place in the world, Charlie Watson discovers Bumblebee, battle-scarred and broken.

Teen Miles Morales becomes the Spider-Man of his universe and must join with five spider-powered individuals from other dimensions to stop a threat for all realities.

A dying CIA agent trying to reconnect with his estranged daughter is offered an experimental drug that could save his life in exchange for one last assignment.